Biomarkers of Disease: An Evidence-Based Approach - download pdf or read online

By Andrew K. Trull, Lawrence M. Demers, David W. Holt, Atholl Johnston, J. Michael Tredger, Christopher P. Price

ISBN-10: 0511064381

ISBN-13: 9780511064388

ISBN-10: 0521811023

ISBN-13: 9780521811026

This new e-book takes a severe, evidence-based examine the efficacy of recent diagnostic exams that are more and more getting used to guage organ harm and disorder. using biomarkers is growing to be, with a gentle movement of latest items being introduced out by means of the pharmaceutical undefined. notwithstanding, in lots of situations the facts which helps using those new tools in place of conventional biochemical checks has now not but been proven, and it truly is meant that this quantity might help make clear the strengths and weaknesses of utilizing those biomarkers throughout quite a lot of purposes and within the numerous organs of the physique. This strategy will offer a useful evaluation of the varied purposes of biomarkers in medication.

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Statistics in Medicine, 8, 431–40. H. D. (1990). Validation of intermediate end points in cancer research. Journal of the National Cancer Institute, 82, 1746–52. I. and Schatzkin, A. (1992). Statistical validation of intermediate endpoints for chronic diseases. Statistics in Medicine, 11, 167–78. R. and De Gruttola, V. (1997). Estimating the proportion of treatment effect explained by a surrogate marker. Statistics in Medicine, 16, 1515–27. 6 Zhou, X-H. (1998). Correcting for verification bias in studies of a diagnostic test’s accuracy.

Bufton a service which converts a collection of numbers and statements into a precise diagnosis and prognosis, and, where appropriate, suggestions for consequent patient management. More than one-half of the responding doctors wanted a wider range of tests. Further probing resulted in the discovery of a huge gap in the awareness of GPs as to the availability of current routine tests. This gap is created, essentially, by the admission of the participating physicians, by an unstructured, unfocused and unsatisfactory education programme within the student medical syllabus.

Therefore, for example, it is of interest to know how useful a reduction in post-treatment cholesterol will be in predicting reductions in the incidence of CAD. Fundamentally, an IE/S should be sufficiently closely related to the CE such that changes in the IE/S accurately predict changes in the CE. 1 The position of an intermediate end-point or surrogate (IE/S) on the pathway between an exposure or intervention (E/I) and a clinical end-point of primary interest (CE). condition that the CE should not be greatly influenced by factors independent of the chosen IE/S.

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Biomarkers of Disease: An Evidence-Based Approach by Andrew K. Trull, Lawrence M. Demers, David W. Holt, Atholl Johnston, J. Michael Tredger, Christopher P. Price

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