Read e-book online Biology of the Lysosome PDF

By John B. Lloyd (auth.), John B. Lloyd, Robert W. Mason (eds.)

ISBN-10: 1461376742

ISBN-13: 9781461376743

ISBN-10: 1461558336

ISBN-13: 9781461558330

From a preview of a prior volume:
`The heterogeneity of topics...is very formidable, and the result's, total, winning as a result top of the range of the person contributions...highly recommended.'
Amercian Scientist.

`Well written and timely...of curiosity to all these interested by the research of this organelle and for these drawn to the scientific and genetic points of lysosomal disorders...recommended.'
Journal of scientific Genetics

Show description

Read Online or Download Biology of the Lysosome PDF

Best biology books

Download e-book for kindle: Nuclear Receptors: A Practical Approach by Didier Picard

The steroid or nuclear receptor superfamily is a crucial workforce of transcription components that's studied by way of a wide and sundry variety of uncomplicated and medical researchers. This publication presents those researchers a useful advisor to take action and is a needs to for all execs in biomedicine.

Read e-book online Biology and Conservation of the European SturgeonAcipenser PDF

The e-book goals at synthesizing our present wisdom of Acipenser sturio and its administration. This species, probably the most common sturgeon species in every single place Western Europe starting from the Black Sea to the Baltic, is now at the verge of extinction. significant elements of its biology and administration, together with mismanagement, are supplied in a old standpoint.

Additional info for Biology of the Lysosome

Sample text

Chapter 2 Origin of Lysosomal Proteins Thomas Braulke 1. INTRODUCTION Lysosomes are the major intracellular site for the degradation of a variety of macromolecules, including proteins, carbohydrates, nucleic acids, and lipids, that are internalized from the extracellular space by endocytosis, delivered by fusion with phagosomes, or derived from the biosynthetic pathway. Lysosomes are enriched with various acid hydrolases that are separated from other cytoplasmic components by a lysosomal membrane.

The analysis of a number of chimeric proteins between cathepsin D and pepsinogen has determined that residues 188-265 in the carboxyl lobe of cathepsin D are able to ensure M6P-independent lysosomal sorting. 1). , 1990) has been described. , 1994), the carrier proteins interacting with the M6P-independent sorting sequences in mammalian cells are still unknown. 5. VESICULAR TRANSPORT MACHINERY Targeting of lysosomal proteins is accomplished by the budding and fusion of transport vesicles. In the past few years genetic and immunolocalization studies as well as reconstituted in vitro systems have contributed to the identification of the components and the molecular mechanisms underlying vesicular transport and membrane trafficking in eukaryotic cells.

Pratten, M. , and Lloyd, 1. , 1986, Pinocytosis and phagocytosis: The effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro, Biochim. Biophys. Acta 881:307-313. Rome, L. , 1985, Curling receptors, Trends Biochem. Sci. 10:151. Seabright, P. , and Smith, G. , 1995, The characterisation of insulin degradation products in endosomes, Biochem. Soc. Trans. 23:IS. Trowbridge, I. , Collawn, J. E, and Hopkins, C. , 1993, Signal-dependent membrane protein trafficking in the endocytic pathway, Annu.

Download PDF sample

Biology of the Lysosome by John B. Lloyd (auth.), John B. Lloyd, Robert W. Mason (eds.)


by Robert
4.0

Rated 4.11 of 5 – based on 6 votes