Get Astrocytes and Epilepsy PDF

By Jacqueline A. Hubbard, Devin K. Binder

ISBN-10: 0128024011

ISBN-13: 9780128024010

ISBN-10: 0128026243

ISBN-13: 9780128026243

Epilepsy is a devastating crew of neurological problems characterised by way of periodic and unpredictable seizure job within the brain.  there's a severe desire for brand new medications and techniques given than no less than one-third of all epilepsy sufferers aren't made freed from seizures through latest medicines and turn into "medically refractory".  a lot of epilepsy learn has fascinated about neuronal healing pursuits, yet present antiepileptic medicinal drugs usually reason serious cognitive, developmental, and behavioral unintended effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity.  moreover, many very important mobile and molecular alterations ensue in astrocytes in epileptic tissue in either people and animal versions of epilepsy.  The objective of Astrocytes and Epilepsy is to comprehensively evaluate intriguing findings linking adjustments in astrocytes to useful alterations liable for epilepsy for the 1st time in publication format.  those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may possibly signify an enormous new healing goal within the keep an eye on of epilepsy. 

Astrocytes and Epilepsy contains historical past explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reports and animal types linking practical alterations in astrocytes to epilepsy.  fantastically labelled diagrams are offered and correct figures from the literature are reproduced to clarify key findings and ideas during this quickly rising field.  Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.

  • Presents the 1st entire e-book to synthesize ancient and up to date examine on astrocytes and epilepsy into one coherent volume
  • Provides a good source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details strength healing ambitions, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Show description

Read Online or Download Astrocytes and Epilepsy PDF

Similar physiology books

Professor Meyer B. Jackson's Molecular and Cellular Biophysics PDF

Delivering complicated undergraduate and graduate scholars with a starting place within the simple techniques of biophysics, scholars who've taken actual chemistry and calculus classes will locate this ebook an available and useful reduction in studying how those recommendations can be utilized in organic learn. The textual content offers a rigorous therapy of the basic theories in biophysics and illustrates their software with examples together with protein folding, enzyme catalysis and ion channel permeation.

Download PDF by Ulrich Förstermann, Huige Li (auth.), Anton Hermann, Guzel: Gasotransmitters: Physiology and Pathophysiology

Because the epochal discovery of the novel and hugely poisonous gasoline nitric oxide (NO) as a signaling molecule, different no much less poisonous gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – were chanced on to even be all in favour of a plethora of physiological and pathophysiological capabilities. The gases termed gasotransmitters play an more and more very important position in figuring out how signalling into and among cells is modulated and fine-tuned.

New PDF release: Proteinuria: Basic Mechanisms, Pathophysiology and Clinical

Fresh paintings has began to explain on the molecular point how albumin is dealt with by means of the kidney and the way albuminuria develops in quite a few proteinuric ailments together with minimum swap affliction and focal segmental glomerulosclerosis. This quantity offers a finished assessment of the renal dealing with of albumin – from uncomplicated mechanisms to the pathophysiology of proteinuric illnesses.

Extra info for Astrocytes and Epilepsy

Sample text

Discussion 8–9. [32] Fields RD. The other brain. New York: Simon & Schuster; 2011. [33] Huntford R. Nansen: the explorer as hero. London: Duckworth; 1997. [34] Forel A. Einige hirnanatomische Betrachtungen und Ergebnisse. Arch. Psychiat. Nervenkr 1887;18(1):162–98. [35] Kuechenhoff B. The psychiatrist Auguste Forel and his attitude to eugenics. Hist Psychiatry 2008;19(74 Pt 2):215–23. [36] Finger S. Minds behind the brain: a history of the pioneers and their discoveries. New York: Oxford University Press; 2000.

87] Del Río-Hortega P. Microglia Penfield W, editor. Cytology and cellular pathology of the nervous system. New York: Hafner; 1932. p. 483–534. [88] Robertson WF. The normal histology and pathology of the neuroglia (in relation specially to mental diseases). J Ment Sci 1897;43:733–52. [89] Robertson WF. A microscopic demonstration of the normal and pathological history of mesoglia cells. J Ment Sci 1900;46:724. [90] Achúcarro N. Nuevo método para el estudio de la neuroglia y del tejido conjuntivo.

Suella Struttura della sostanza grigia del cervello (comunicazione preventiva). Gazzetta Medica Italiana, Lombardia. 1873;33:244–246. ASTROCYTES AND EPILEPSY 36 1. History of Astrocytes [52] Golgi C. Opera omnia. Milano: Hoepli; 1903. [53] Golgi C. Contribuzione alla fina Anatomia degli organi centrali del sistema nervosos. Rivista clinica di Bologna; 1872;2:38–46. [54] Ramón y Cajal S. Contribución al conocimiento de la neuroglia del cerebro humano. Trab Lab Invest Biol 1913;11:255–315. [55] Del Río-Hortega P.

Download PDF sample

Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder


by James
4.5

Rated 4.41 of 5 – based on 24 votes