By Jacqueline A. Hubbard, Devin K. Binder
Epilepsy is a devastating crew of neurological problems characterised by way of periodic and unpredictable seizure job within the brain. there's a severe desire for brand new medications and techniques given than no less than one-third of all epilepsy sufferers aren't made freed from seizures through latest medicines and turn into "medically refractory". a lot of epilepsy learn has fascinated about neuronal healing pursuits, yet present antiepileptic medicinal drugs usually reason serious cognitive, developmental, and behavioral unintended effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity. moreover, many very important mobile and molecular alterations ensue in astrocytes in epileptic tissue in either people and animal versions of epilepsy. The objective of Astrocytes and Epilepsy is to comprehensively evaluate intriguing findings linking adjustments in astrocytes to useful alterations liable for epilepsy for the 1st time in publication format. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may possibly signify an enormous new healing goal within the keep an eye on of epilepsy.
Astrocytes and Epilepsy contains historical past explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reports and animal types linking practical alterations in astrocytes to epilepsy. fantastically labelled diagrams are offered and correct figures from the literature are reproduced to clarify key findings and ideas during this quickly rising field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st entire e-book to synthesize ancient and up to date examine on astrocytes and epilepsy into one coherent volume
- Provides a good source at the box of astrocyte biology and astrocyte-neuron interactions
- Details strength healing ambitions, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder