Arenaviruses: Biology and Immunotherapy by M. B. A. Oldstone (auth.), Michael B. A. Oldstone M.D. PDF

By M. B. A. Oldstone (auth.), Michael B. A. Oldstone M.D. (eds.)

ISBN-10: 3642717268

ISBN-13: 9783642717260

ISBN-10: 3642717284

ISBN-13: 9783642717284

M. B. A. OLDSTONE Viruses are as a rule studied both simply because they reason major human, animal or plant affliction or for his or her application as fabrics to probe a uncomplicated phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are surprisingly attention-grabbing in that they occupy either one of those different types. Arenaviruses reason serious human ailments recognized basically because the hemor­ rhagic fevers taking place in South and Latin the USA (Bolivia: Machupo virus and Argentina: Junin virus) and in Africa (Lassa virus). simply because such viruses produce profound incapacity and should kill the people they infect, they seem to be a resource of financial complication within the international locations the place they're typical. extra, they supply new difficulties for overall healthiness care body of workers due to the narrowing of the realm as viewers from many nations more and more trip to and from those endemic components. moreover, lymphocytic choriomeningitis virus (LCMV) can infect people world wide, even though the affliction is in general much less disabling than these elicited by means of different arenaviruses. but LCMV is probably going of better difficulty to non-arena-virologists and experimentalists utilizing tissue tradition or animals, i. e. , staff in molecular biology, melanoma study, virology, immunobiology, and so on. , simply because basic showing cultured cells or tissues and animals used for study will be repeatedly contaminated with LCMV with out manifesting scientific illness or cytopathology and transmit that an infection to laboratory staff (reviewed OLDSTONE and PETERS 1978). for instance, HINMAN et al.

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It is tempting to speculate that these lesions represent pathologic correlates of viral involvement of the autonomic nervous system. Such lesions could explain the hypotension, flushing, or gastrointestinal disturbances so characteristic of this disease. Viremia was undetectable in Romero infection. With Ledesma, serum viral titers were consistently less than 3 loglo PFU Iml and of brief duration, while in Espindola-infected animals, pronounced serum viremias (generally 5-710g1o PFU Iml) were observed that frequently persisted at titers exceeding 3 loglo PFU Iml until death.

On one occasion 12 cynomolgus macaques were introduced when guinea pigs and mice had been infected with a virulent Lassa viral strain 12 days previously. Two of these monkeys became infected and died within 3 weeks, yielding Lassa virus from all organs tested. J. Peters et al. overt disease while being conditioned before inoculation with Lassa virus. Transmission of virus between monkeys is possible; urine is frequently infectious, even late into convalescence. However, infection of monkeys in our experience has always occurred in the presence of Lassa virus-infected guinea pigs or mice.

J. Peters et al. 13. c. c. a have attempts to adapt Pichinde virus to produce a murine HF model by sequential spleen-to-spleen passage been successful (JAHRLING, unpublished results). Since adapted Pichinde (like guinea pig-lethal Lassa virus strains) replicates earlier and to higher titer in strain 13 guinea pigs than its parent (JAHRLING et al. 1981), we compared selected biological properties that have correlated with the virulence of other viruses. Adsorption rates for parental and adapted Pichinde to guinea pig peritoneal macrophages were very similar, as were growth rates in these cells.

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Arenaviruses: Biology and Immunotherapy by M. B. A. Oldstone (auth.), Michael B. A. Oldstone M.D. (eds.)


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