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By J. Skoda, Peter Langen

ISBN-10: 0080243843

ISBN-13: 9780080243849

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Extra info for Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978

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A. 75, 980 (1978). J. Galivan, G. F. Maley, and F. Maley, Purification and properties of T2 bacteriophage-induced thymidylate synthetase, Biochemistry 13, 2282 (1974). J. H. Galivan, G. F. Maley, and F. Maley, Factors affecting substrate binding in Lactobacillus casei as studied by equilibrium dialysis, Biochemistry 15, 356 (1976). J. R. Bertino, W. L. Sawicki, C. A. Lindquist, and V. S. Gupta, Schedule-dependent antitumor effects of methotrexate and 5fluorouracil, Cancer Res. 37, 327 (1977). C.

Santi and Τ. T. Sakai, Biochem. Biophys. Res. Comm. 46, 1320 (1972). (7) P. Reyes and C. Heidelberger, Molec. Pharmacol. 1, 14 (1965). (8) D. V. Santi, A. L. Pogolotti, T. L. James, Y. Wataya, Κ. M. Ivanetich, and S. S. M. Lam, ACS Symp. , No. 28, 52 Inhibitors of Thymidylate Synthetase 57 (1976). (9) D. V. Santi and C. S. McHenry, Proc. Natl. Acad. Sci. A. 69, 1855 (1972). (10) R. J . Langenbach, P. V. Danenberg and C. Heidelberger, Biochem. Biophys. Res. Comm. 48, 1565 (1972). [11) D. V. Santi, C.

The parameter MR is often used as a measure of dispersion forces (17,18) when the term is associated with a positive coefficient; however, MR is also a measure of volume (units of cc/mol), and we interpret the negative coefficient associated with this parameter to indicate that the MR term reflects a steric effect between the 5-substituent of the ligands and the enzyme. From eq. 3, certain conclusions may be reached regarding the effects of 5-substituents on the inhibitory power of deoxyuridylates.

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Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978 by J. Skoda, Peter Langen


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