By Tadashi Inagami, Masato Mizukoshi, Deng-Fu Guo (auth.), Juan M. Saavedra, Pieter B. M. W. M. Timmermans (eds.)
From molecular biology to scientific functions of selective receptor blockade, the current quantity compiles the newest advances of this rising box. Of specific significance is the eye given to the newly stumbled on AT2 receptors, and the body structure and pathophysiology of angiotensin receptor subtypes. The publication will supply clinicians treating heart problems and high blood pressure with a clearer realizing of this therapeutically vital and intricate hormone.
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Extra resources for Angiotensin Receptors
REFERENCES 1. Peach MJ: Molecular actions of angiotensin. Biochem Pharmacol 30:2745-2751, 1981. 2. Douglas JC: Angiotensin receptor sUbtypes of the kidney cortex. Am J Physiol 253 (Renal Fluid Electrolyte Physiol 22): FI-F7, 1987. 3. Whitebread S, Mele M, Kamber B, et al: Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun 163:284-291, 1989. 4. Chiu AT, Herblin WF, McCall DE, et al: Identification of angiotensin II receptor sUbtypes. Biochem Biophys Res Commun 165:196-203, 1989.
Although the ATl receptor expression levels are relatively stable during these in vitro manipulations, more detailed studies are needed to resolve some of the disagreements in results from different laboratories. 7. FUTURE DIRECTIONS The cloning of AT 1 receptor has already resolved many important questions and confirmed the hypotheses postulated without using purified receptors. The use of cDNAs has made it possible to determine the level of ATl gene expression and also to transiently or permanently express native or mutated ATl receptors.
It became rapidly evident that all of the functions of ANG II known at the time were exclusively mediated by ATI receptors. Thus, ANG II-stimulated inositol phosphate fonnation in rat hepatocytes and vascular smooth muscle cells, calcium mobilization in rat cardiomyocytes and vascular smooth muscle cells, and contraction of rat mesangial cells and rabbit aorta were totally blocked (via an apparent competitive mechanism) by AT) and unaffected by AT2 antagonists. 18 ,23-26 ANG II-induced inhibition of adenylate cyclase in rat liver membranes was also sensitive to ATI but not AT2 antagonists,27 In addition, ANG II-induced protein synthesis and [3H]thymidine incorporation in rat vascular smooth muscle cells were abolished by ATI antagonists.
Angiotensin Receptors by Tadashi Inagami, Masato Mizukoshi, Deng-Fu Guo (auth.), Juan M. Saavedra, Pieter B. M. W. M. Timmermans (eds.)