By Gary M. Drzewiecki Ph.D., John K-J. Li Ph.D. (auth.)
The goal of this e-book is to supply the researcher and clinician with the new advancements within the research and review of cardiovascular func tion. The chapters are geared up into sections that correspond with many of the anatomical degrees of the cardiovascular procedure. To a wide volume, fresh concentrate on the cardiovascular method functionality has been directed on the molecular point to the close to exclusion of the tissue and organ functionality. whereas this can be worthy in constructing new healing medications, it doesn't reduction the heart specialist or doctor, who frequently care for sufferer indicators. This ebook integrates the micro-level and organ-level functionality in order that new infor mation might be assimilated into the cardiovascular process as a complete. inside of each one part, the chapters were prepared to development from contemporary theoretical advancements, to experimental learn, and eventually to scientific functions. This technique allows the well timed move of infor mation from uncomplicated learn to the sanatorium. The energy of the analytical strategy should be obvious to the reader. The theoretical research deals information to experimental layout and, from time to time, deals options the place measurements are as but inconceivable. In relocating from newly attained wisdom to scientific perform, this e-book emphasizes the noninvasive meth sooner or later as technological advances ods. Such tools are fascinating happen and the fad in the direction of early preventive analysis is sought. What follows are highlights of latest advancements lined in each one element of the book.
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Additional resources for Analysis and Assessment of Cardiovascular Function
Ca2+ must therefore diffuse from the thick-thin unit ends inward for contraction to occur, which produces a second source of contractile asynchrony. Features 1 through 3 suggest a raster type bond activation. Consider five thick-thin units in series that are stimulated at the left end. Bonds are attached sequentially as the electrical stimulus propagates from left to right. The pattern then repeats as Ca2+ diffuses inward toward the centers of the thick-thin units from release sites near the Z-lines.
1927;3:212. 20. Li JK-J. Arterial System Dynamics. New York: New York University Press; 1987. 21. Li JK-J, Melbin J, Riffle RA, Noordergraaf A. Pulse wave propagation. Circulation Res. 1981;49:442-452. 22. Li JK-J. A new similarity principle for cardiac energetics. Bull Math BioI. 1983;45:1005-1011. 23. Li JK-J. Hemodynamic significance of metabolic turnover rate. J Theor BioI. 1983;103:333-338. 2. A New Approach to the Analysis of Cardiovascular Function 29 24. Li JK-J. Comparative cardiac mechanics: Laplace's law.
The thick filament masses remain m as before. The collective mass of the Z-line and the attached thin filaments is described by the mass m*. Expansion of the model to N series sarcomeres, each with M parallel pairs of active bonds gives a total of 2NM + (4N - 1) equations, which are written as 2NM + (6N - 2) simultaneous, first-order differential equations, and solved with initial conditions LlZl(O), Llz2(0), ... , LlZ 2N_1(0), Llzij(O) for i = 1, 2, ... , M and j = 1, 2, ... , N. The muscle model was developed from a small number of bonds to a final fiber configuration of 50 series sarcomeres each with 50 parallel (lumped) pairs of bonds, yielding 5298 simultaneous differential equations.
Analysis and Assessment of Cardiovascular Function by Gary M. Drzewiecki Ph.D., John K-J. Li Ph.D. (auth.)