By Perkin G David
Any dialogue of the scientific features of Parkinson's ailment needs to have in mind the inaccuracies of scientific analysis. In a successive sequence of a hundred sufferers with a medical prognosis of Parkinson's disorder, purely seventy six fulfilled the standards for prognosis at autopsy exam. makes an attempt to tighten the diagnostic standards result in elevated specificity yet with decreased sensitivity.In An Atlas of Parkinson's sickness and comparable problems Dr. David Perkin has compiled a chain of images highlighting a number of points of Parkinson's illness and similar motor issues. The booklet presents an invaluable pattern of medical, investigative (CT, MRI, and puppy) and pathological photographs with succinct descriptive textual content of the problems featured. nearly one-third of the cloth during this publication is pathological, incorporating either macroscopic and microscopic sections. an extra region of the fabric is represented through imaging, largely magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning. the realm of move issues has been fairly fruitful for puppy scanning, which grants, with the improvement of particular ligands for many of the receptor websites, to extra extend realizing of the pathophysiological mechanisms of the move problems. Reflecting the top criteria medical images and imaging besides the prestigious author's specialist wisdom of the topic, Dr. Perkin's An Atlas of Parkinson's sickness and similar problems is the definitive and crucial scientific reference in its box.
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Additional info for An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series)
11C-raclopride is a selective reversible antagonist of D2 receptors) Figure 33 Coronal section of brain from a patient with striatonigral degeneration showing symmetrical atrophy and discoloration of the putamen ©2004 CRC Press LLC Figure 34 Histology of striatonigral degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press LLC Figure 36 Axial (upper) and coronal (lower) T2-weighted MRIs showing putaminal hypointensity (arrowed) in a patient with striatonigral degeneration ©2004 CRC Press LLC Figure 37 Coronal sections showing normal (upper) compared with atrophied (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in a control subject (left) compared with neuronal depletion (right) in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 39 Multiple system atrophy with olivopontocerebellar atrophy.
Evidence of Purkinje cell degeneration (right) with formation of axon torpedoes (white arrow) is seen in the molecular layer (H & Es) ©2004 CRC Press LLC Figure 40 Histological sections showing examples of oligodendroglial cytoplasmic inclusions in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 41 Sagittal T1-weighted MRI showing pontine (black arrow) and cerebellar (white arrow) atrophy in a patient with olivopontocerebellar atrophy ©2004 CRC Press LLC Figure 42 T2-weighted MRI (upper) shows hyperintensity of the middle cerebellar peduncles and the cerebellum.
C, P, caudate nucleus and putamen (striatum); GP, globus pallidus (e, externa; i, interna); SN, substantia nigra (c, compacta; r, reticulata); Sth, subthalamic nucleus; T, thalamus (nuclei: VA, ventral anterior; VL, ventrolateral; CM, centromedian; I, other intralaminar); SC, superior colliculus. , Neurology in Clinical Practice, 1996 (see page 31) MC/SMA/PMC PUTAMEN D2 MC/SMA/PMC PUTAMEN D1 D2 D1 direct pathway indirect pathway SNc SNc VLo VApc/mc CM GPe STN GPe VLo VApc/mc CM STN GPi/SNr Brain stem Spinal cord ©2004 CRC Press LLC GPi/SNr Figure 2 Connections of striatal output neurons in controls (left) and in rats with 6-0H dopamine lesions of the nigrostriatal dopamine system (right).
An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series) by Perkin G David