By Klaus Ley
Inflammatory cellphone recruitment calls for the concerted motion of not less than 5 significant units of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate buildings serving as selectin ligands, and sure ectoenzymes. This quantity supplies a accomplished review at the such a lot appropriate leukocyte and endothelial adhesion molecules. The chapters are written via leaders within the box and concentrate on the biology, constitution, functionality, and law of adhesion molecules. at the moment licensed adhesion molecule-based cures are reviewed and an outlook for destiny ways can also be provided.
The e-book is of curiosity to clinicians and scientists from immunology, body structure, melanoma study, rheumatology, allergology, infectious ailments, gastroenterology, pulmonology and cardiology.
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Extra info for Adhesion Molecules: Function and Inhibition
Blood 83: 2498–2507 McEver RP, Martin MN (1984) A monoclonal antibody to a membrane glycoprotein binds only to activated platelets. J Biol Chem 259: 9799–9804 Hsu-Lin SC, Berman CL, Furie BC, August D, Furie B (1984) A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets. J Biol Chem 259: 9121–9126 Alon R, Hammer DA, Springer TA (1995) Lifetime of the P-selectin: carbohydrate bond and its response to tensile force in hydrodynamic flow.
However, despite the identification of numerous ligands that can be recognized by L-selectin, defining any of these molecules as the physiological ligand for L-selectin remains difficult. For example, genetically targeted mice deficient in expression of GlyCAM-1, CD34 or both demonstrate normal L-selectin-dependent leukocyte adhesion and migration [53, 54]. Therefore, either these molecules do not function as physiological L-selectin ligands in vivo or there is a high degree of redundancy among ligands.
Selectin-ligand interactions are dynamic and involve the constant formation (Kon) and dissociation (Koff) of bonds depending on the shear forces exerted on the leukocyte due to the flow of blood. Forces above a specific threshold are required for the formation of functional tethers between Lselectin and its ligand [119, 120]. Importantly, L-selectin mediates rolling at faster velocities as compared to the other selectins implying that the Kon and Koff for Lselectin are higher than that for P- and E-selectin.
Adhesion Molecules: Function and Inhibition by Klaus Ley