David T. Curiel's Adenoviral Vectors for Gene Therapy, Second Edition PDF

By David T. Curiel

ISBN-10: 012800276X

ISBN-13: 9780128002766

Adenoviral Vectors for Gene remedy, moment Edition presents specific, entire insurance of the gene supply cars which are in line with the adenovirus that's rising as an immense instrument in gene remedy. those intriguing new healing brokers have nice strength for the remedy of affliction, making gene treatment a fast-growing box for study.

This publication offers themes starting from the elemental biology of adenoviruses, in the course of the development and purification of adenoviral vectors, state-of-the-art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory matters surrounding human medical gene remedy trials. This large scope of knowledge offers a high-quality evaluation of the sphere, permitting the reader to realize a whole figuring out of the improvement and use of adenoviral vectors.

  • Provides entire assurance of the elemental biology of adenoviruses, in addition to their development, propagation, and purification of adenoviral vectors
  • Introduces universal options for the improvement of adenoviral vectors, in addition to state of the art equipment for his or her improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses application of adenoviral vectors in animal illness models
  • Considers Federal Drug management laws for human scientific trials

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Additional info for Adenoviral Vectors for Gene Therapy, Second Edition

Example text

55 Further investigations are required to elucidate the physiological roles of SR and other attachment factors in natural and therapeutic infections of model organisms and humans. 132 They are located on the basolateral side of polarized epithelia but can be relocated apically in the context of infection. Integrins are in a dynamic equilibrium between active ligand-bound and inactive ligand-free states. 134 Integrins occur as 24 α/β heterodimers of 18 α and 8 β subunits. 8 Extracellular Factors Influencing Viral Tropism Body fluids contain factors that bind to AdVs, confer alternative viral tropism, and influence the outcome of both natural infection and systemic gene therapy.

J Virol 2006;80:11881–6. Boudin ML, D’Halluin JC, Cousin C, Boulanger P. Human adenovirus type 2 protein IIIa. II. Maturation and encapsidation. Virology 1980;101:144–56. Chroboczek J, Viard F, D’Halluin JC. Human adenovirus 2 temperature-sensitive mutant 112 contains three mutations in the protein IIIa gene. Gene 1986;49:157–60. San Martin C, Glasgow JN, Borovjagin A, Beatty MS, Kashentseva EA, Curiel DT, et al. Localization of the N-terminus of minor coat protein IIIa in the adenovirus capsid.

Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science 1999;286:1579–83. Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N. Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. J Virol 2004;78:7727–36. Cupelli K, Muller S, Persson BD, Jost M, Arnberg N, Stehle T. Structure of adenovirus type 21 knob in complex with CD46 reveals key differences in receptor contacts among species B adenoviruses. J Virol 2010;84:3189–200.

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Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel


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